VIVOPATH offers preclinical support services which move compounds from the chemistry bench to definition of a Therapeutic Index and evaluation of potential as a development candidate. Services fall into four key areas:
Formulation Services
Formulation for in vivo administration
Optimization for oral bioavailability
Experience with proteins, peptides, small molecules and nucleic acids
Tissue Distribution and Pharmacokinetic Evaluation
Multiple routes and species
Bioavailability and pk parameter determination
Evaluation in tumor-bearing mice
Localization of compound using in vivo imaging
Efficacy Testing
Predictive models in metabolic, inflammatory and infectious diseases
Models available in house and require very little lead time
Model development, pharmacological validation and compound screening